Seminar: "Metaorganismal Endocrinology: Microbe-Derived Signals Shape Host Metabolic Homeostasis" - J. Mark Brown, Ph.D.
Nutritional Sciences Seminar
J. Mark Brown, Ph.D.
Associate Staff, Director of Research, Center for Microbiome & Human Health
Cleveland Clinic
Following a meal resident bacteria living our intestine metabolize macro- and micronutrients to generate unique small molecule, protein, and lipid metabolites that can systemically circulate at high levels. Gut microbe-derived nutrient metabolites can act very much like endocrine hormones where they engage host receptors to elicit meal-related physiologic responses in the host. This talk will cover emerging evidence that metaorganismal (i.e. microbe-host) endocrine pathways are associated with cardiometabolic disease and will discuss drug discovery strategies targeting the gut microbial endocrine organ.